How to Think: Clinical Research (Session 1)

June 11, 2021
2:00 pm - 3:00 pm
CSRB 4th floor seminar room, 4939 Childrens Pl, St. Louis, MO 63110

We will spend about 45 minutes providing a brief overview of the following 10 points (3-4 minutes per point). In the last 10-15 minutes, via a group discussion, we will identify a problem (suggested by students) that we want to address by performing a clinical trial.

Goal: Provide an overview of the thought process in designing a clinical study.

  • Identification of a clinically meaningful problem
  • Evaluation of the existing knowledge base about the problem
  • Forming a hypothesis
  • Testing a hypothesis in human subjects
  • Brief overview of types of clinical studies
  • Defining your primary outcome
  • Determining your study design
  • Rationale for determining inclusion and exclusion criteria
  • Sample size and power
  • Efficacy, effectiveness, toxicity and safety